Use of Genetics in testing Uterine Receptivity (ENDOMETRIAL RECEPTIVE TEST)

Endometrial receptivity is a complex process, which involves an embryo attaching to maternal uterus and invading, developing and finally culminating into a new individual. The window of implantation extends 3-6 days within the second half of menstrual cycle. In some cases this window can be short or shifted precluding normal implantation leading to infertility or pregnancy loss.

Endometrial receptivity assay defines the time, when uterine environment and window of implantation (WOI) in the uterus is ready for acceptance of the embryo and hence subsequent implantation.

There are various ways to assess endometrial receptivity such as with pelvic ultrasound, doppler study of uterus and by genetic testing.

Genetic assessment of window of implantation involves assessment of 258 genes in endometrium which are responsible for endometrial implantation process. It tries to find out the personalised window of implantation and personalised time of transfer. Once window is assessed, embryos are transferred in a frozen embryo replacement cycle. This procedure of endometrial receptivity test involves taking endometrial biopsy and studying RNA genetic material. It is mainly indicated for couples with recurrent implantation failures wherein transfer of good quality blastocyst have already been tried.

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